Neil Spector
Personal Home Page
http://www.dukehealth.org/physicians/DC0792ECDB1504C6852571F600719502
Articles in Scholarly Journals [Incomplete List]
- Rational Development of Targeted Cancer Therapies Using Biomarkers
Laboratory Medicine, vol. 37, no. 8, pp. 482–489, 2008 - Lapatinib Antitumor Activity Is Not Dependent upon Phosphatase and Tensin Homologue Deleted on Chromosome 10 in ErbB2-Overexpressing Breast Cancers
Cancer Research, vol. 67, no. 3, pp. 1170–1175, 2007 - A reciprocal tensin-3–cten switch mediates EGF-driven mammary cell migration
Nature Cell Biology, vol. 9, no. 8, Article ID ncb1622, 8 pages, 2007 - Activation of AMP-activated protein kinase by human EGF receptor 2/EGF receptor tyrosine kinase inhibitor protects cardiac cells
Proceedings of the National Academy of Sciences, vol. 104, no. 25, pp. 10607–10612, 2007 - A model of acquired autoresistance to a potent ErbB2 tyrosine kinase inhibitor and a therapeutic strategy to prevent its onset in breast cancer
Proceedings of the National Academy of Sciences, vol. 103, no. 20, pp. 7795–7800, 2006 - Regulation of Survivin by ErbB2 Signaling: Therapeutic Implications for ErbB2-Overexpressing Breast Cancers
Cancer Research, vol. 66, no. 3, pp. 1640–1647, 2006 - Study of the Biologic Effects of Lapatinib, a Reversible Inhibitor of ErbB1 and ErbB2 Tyrosine Kinases, on Tumor Growth and Survival Pathways in Patients With Advanced Malignancies
Journal of Clinical Oncology, vol. 23, no. 11, pp. 2502–2512, 2005 - Combining lapatinib (GW572016), a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases, with therapeutic anti-ErbB2 antibodies enhances apoptosis of ErbB2-overexpressing breast cancer cells
Oncogene, vol. 24, no. 41, Article ID 1208774, 8 pages, 2005 - Phase I pharmacokinetic studies evaluating single and multiple doses of oral GW572016, a dual EGFR-ErbB2 inhibitor, in healthy subjects
Investigational New Drugs, vol. 23, no. 1, pp. 39–49, 2005 - Truncated ErbB2 receptor (p95ErbB2) is regulated by heregulin through heterodimer formation with ErbB3 yet remains sensitive to the dual EGFR/ErbB2 kinase inhibitor GW572016
Oncogene, vol. 23, no. 3, Article ID 1207166, 7 pages, 2004 - A Phase I trial of preoperative eniluracil plus 5-fluorouracil and radiation for locally advanced or unresectable adenocarcinoma of the rectum and colon1
International Journal of Radiation OncologyBiologyPhysics, vol. 58, no. 3, pp. 779–785, 2004 - Breast Cancer Research and Treatment, vol. 77, no. 3, pp. 233–243, 2003
- Anti-tumor activity of GW572016: a dual tyrosine kinase inhibitor blocks EGF activation of EGFR/erbB2 and downstream Erk1/2 and AKT pathways
Oncogene, vol. 21, no. 41, Article ID 1205794, 8 pages, 2002 - Sensitization of tumor cells to Fas killing through overexpression of heat-shock transcription factor 1
Journal of Cellular Physiology, vol. 183, no. 3, pp. 425–431, 2000 - Tumor selective G2/M cell cycle arrest and apoptosis of epithelial and hematological malignancies by BBL22, a benzazepine
Proceedings of the National Academy of Sciences, vol. 97, no. 13, pp. 7494–7499, 2000 - Truncation of Sp1 transcription factor by myeloblastin in undifferentiated HL60 cells
Journal of Cellular Physiology, vol. 175, no. 2, pp. 121–128, 1998 - Activation signals regulate heat shock transcription factor 1 in human B lymphocytes
Journal of Cellular Physiology, vol. 170, no. 3, pp. 235–240, 1997 - 28-kDa Mammalian Heat Shock Protein, a Novel Substrate of a Growth Regulatory Protease Involved in Differentiation of Human Leukemia Cells
Journal of Biological Chemistry, vol. 270, no. 3, pp. 1003–1006, 1995 - Heat shock protein is a unique marker of growth arrest during macrophage differentiation of HL-60 cells
Journal of Cellular Physiology, vol. 156, no. 3, pp. 619–625, 1993 - Activation primes human B lymphocytes to respond to heat shock
Journal of Experimental Medicine, vol. 170, no. 5, pp. 1763–1768, 1989