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Table 2: SVM analysis accurately predicts future disease severity in RA patients using ERA 19-gene expression profiles as the training set.

Training set input Patient sample SVM input 19-gene class Clinical class ERA1 Severe Severe Severe ERA2 Mild Mild Mild ERA3 Mild Mild Mild ERA4 Mild Mild Mild ERA6 Severe Severe Severe ERA8 Mild Mild Mild ERA9 Mild Mild Mild ERA12 Severe Severe Severe ERA13 Severe Severe Severe ERA14 Severe Severe Severe ERA15 Mild Mild Mild ERA16 Mild Mild Mild ERA20 Mild Mild Mild ERA21 Severe Severe Severe ERA22 Severe Severe Severe ERA24 Mild Mild Mild ERA25 Severe Severe Severe Classified set output Patient sample SVM input SVM output Clinical class RA1 Unassigned Mild Severe RA2 Unassigned Severe Severe RA3 Unassigned Mild Mild RA4 Unassigned Severe Severe RA5 Unassigned Severe Severe RA6 Unassigned Severe Severe RA7 Unassigned Mild Mild RA8 Unassigned Mild Mild RA9 Unassigned Mild Mild

Details of the analysis are described in the text.